8297至尊品牌游戏官方网站

基本信息

招生专业

硕士生: 发酵工程 

教育与工作经历

8297至尊品牌游戏官方网站:

8297至尊品牌游戏官方网站:教育经历

• 1992.9—1996.6   重庆大学                      精细化工   本科

• 2000.9—2003.3   中国科8297至尊品牌游戏官方网站北京化学所          分析化学   硕士

• 2003.5—2007.2   Stuttgart University（德国）  物理化学   博士

8297至尊品牌游戏官方网站:工作经历

• 2014.10 — 目前   副教授，华南理工大学 生物科学与工程8297至尊品牌游戏官方网站

  • 2008.8 — 2014.9   Post-doctoral Scholar,  Penn State University（美国）

  • 2006.5—2007.2   Teaching assistant，Stuttgart University（德国）

  • 1996.7—2000.5   技术员，中国重庆三峡油漆股份有限公司

教学与科研情况

8297至尊品牌游戏官方网站:教学

本科生教学：主讲：生物药剂学、有机化学、大学化学

本科生导师制：7位8297至尊品牌游戏官方网站

研究生教学：参与授课：酶学与酶工程

教学成果：

8297至尊品牌游戏官方网站:科研

科研兴趣：生物大分子结构、运动与功能的关系；生物大分子与小分子化合物的相互作用等

科研项目：主持国家自然科学基金面上项目、广州市科学研究一般专项等

代表性成果

[1] Huiping Liu, Yanyun Zhu, Xiaorong Yang*（通许作者）, Ying Lin*, Four second-sphere residues of Thermus thermophilus SG0.5JP17-16 laccase tune the catalysis by hydrogen-bonding networks, Appl Microbiol Biotechnol, 2018, 102(9), 4049-4061.

[2] Xiaorong Yang*, Conformational dynamics play important roles upon the function of N-acetyl glutamate kinase, Appl Microbiol Biotechnol, 2017, 101(9), 3485-3492.

[3] Xiaorong Yang, Xinran Liu, Derek M. Musser, Ibrahim M Moustafa, Jamie J. Arnold, Craig E. Cameron and David D. Boehr, Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases, J Biol Chem. 2017, 292(9), 3810-3826.

[4] Yuanyuan Huang, Cheng Li, Hao Zhang, Shuli Liang, Shuangyan Han, Ying Lin, Xiaorong Yang*（通许作者）, Suiping Zheng*, Monomeric Corynebacterium glutamicum N-acetyl glutamate kinase maintains sensitivity to L-arginine but has a lower intrinsic catalytic activity, Appl Microbiol Biotechnol, 2016, 100(4), 1789-1798.

[5] Xinran Liu, Derek M. Musser, Cheri A. Lee, Xiaorong Yang, Jamie J. Arnold, Craig E. Cameron and David D. Boehr, Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase, Viruses, 2015, 7, 5571-5586.

[6] Ibrahim M Moustafa, Victoria S Korneeva, Jamie J Arnold, Eric D Smidansky, Laura L Marcotte, David W Gohara, Xiaorong Yang, Maria A Sánchez-Farrán, David Filman, Janna K Maranas, David D Boehr, James M Hogle, Coray M Colina, Craig E Cameron, Structural Dynamics as a Contributor to Error-prone Replication by a RNA-dependent RNA Polymerase, J Biol Chem. 2014, 289, 36229-36248.

[7] David D Boehr, Xinran Liu, Xiaorong Yang, Targeting structural dynamics of the RNA-dependent RNA polymerase for anti-viral strategies. Curr Opin Virol. 2014, 9, 194-200.

[8] Xinran Liu, Xiaorong Yang (共同第一作), Cheri A. Lee, Ibrahim M. Moustafa, Eric D. Smidansky, David Lum, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity, J Biol. Chem. 2013, 288, 32753-65.

[9] Yan M Chan, Xiaorong Yang, David D Boehr, The Role of Phosphatidylinositol Phosphates (PIPs) in Poliovirus Replication Complexes Trafficking to Viral Replication Organelles, BIOPHYSICAL JOURNAL, 2013, 104(2), Supplement:1, Pages:98A-98A.

[10] Ibrahim M Moustafa, Victoria S Korneeva, Jamie J Arnold, Eric D Smidansky, Laura L Marcotte, Xiaorong Yang, Janna K Maranas, David D Boehr, James M Hogle, Coray M Colina, Craig E Cameron, Nanosecond-Timescale Dynamics of the Viral RNA-Dependent RNA Polymerase as a Determinant of Incorporation Fidelity, BIOPHYSICAL JOURNAL, 2013, 104(2), Supplement:1, Pages:213A-213A.

[11] Xiaorong Yang, Eric D. Smidansky, Kenneth R. Maksimchuk, David Lum, Jesse L. Welch, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition, Structure, 2012, 20, 1519-1527.    

[12] Xiaorong Yang*, Klaus Müller, The guest ordering and dynamics in urea inclusion compounds studied by solid state 1H and 13C MAS NMR spectroscopy, J. Mol. Struct. 2011, 1006, 113-120. 

[13] Xiaorong Yang*, Klaus Müller, The structural and dynamic properties of 1-bromodecane in urea inclusion compounds investigated by solid state 1H, 13C and 2H NMR spectroscopy, Magn. Reson. Chem. 2011, 49, 514-522.   

[14] Xiaorong Yang, Jesse L. Welch, Jamie J. Arnold, David D. Boehr, Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance, Biochemistry, 2010, 49, 9361-9371.

[15] Xiaorong Yang, Klaus Müller, Solid state NMR investigations on urea inclusion compounds: Order and dynamics of 1, 6-dibromohexane, J. Mol. Struct. 2007, 831, 75- 89.     

[16] Xiaorong Yang, Klaus Müller, Solid state NMR studies of the guest ordering and dynamics in α, w-dibromoalkane/urea inclusion compounds, Appl. Magn. Reson. 2007, Vol. 32, No. 3, 407-431.    

[17] Junfeng Xiang, Xiaorong Yang, Ciping Chen, Yalin. Tang, Wenpeng Yan, Guangzhi Xu, Effects of NaCl on the J-aggregation of Two Thiacarbocyanine Dyes in the Aqueous Solutions, J. Colloid Interface Sci. 2003, Vol. 258, 198-205.

[18] Xiaorong Yang, Tongxin Wang, Deqing Zhang, Yalin Tang, Lipu Li, Keyue Hou, NMR Relaxation Times of Alkanethiol Monolayer Self-assembling on Nano-scale Gold Particles, Acta Chimica Sinica. 2002, Vol. 60, No. 9, 1575-1580.

1. Ph D Thesis Book：

   Xiaorong Yang, Solid-State NMR Studies of the Guest Molecules in Urea Inclusion Compounds, Logos Verlag, Berlin, ISBN 978-3-8325-1533-1.

2. 发明专利：

   一种提高染料脱色效率的漆酶突变体及其制备方法与应用，杨小蓉，祝艳云，林影，刘慧平，申请号：201810170225.X.