报告题目：Portable medical platforms based on aggregation-induced emission biosensors for quantitative detection of urine biomarkers: Design, development, and clinical evaluation

报 告 人：唐友宏 教授（澳大利亚弗林德斯大学）

邀 请 人：秦安军 教授

报告时间：2023年7月6日（周四）上午9:30-11:00

报告地点：北区发光材料与器件国家重点实验室502会议室

报告摘要：Body fluids are used as a means of examining various biomarkers of health and disease both as a means of rapid diagnosis and monitoring of chronic health conditions. Biomarker detection in non-invasively collected biofluids is considered an easy and rapid method in medical diagnostics [1]. A novel group of bioprobes with aggregation-induced emission (AIE) properties is being developed for monitoring analytes in biofluids which could facilitate widespread use via commonly available technologies [2]. For example, urinalysis is extremely useful in the clinical diagnosis, detection, and treatment of disorders such as urinary tract infections, renal disease, and chronic kidney disease (CKD) [3]. CKD is a global health issue, and screening high-risk population with albumin-to-creatinine ratio (ACR) urine test will identify patients with CKD early [4-5]. This will provide opportunity for early inventions to prevent CKD progressing to end-stage kidney disease. In this study, we synthesize and screen suitable AIE biosensors for albumin and creatinine [3, 6], develop the relevant colorimetric /fluorescent medical platforms to facilitate the quantitatively detection [7], clinically evaluate the AIEgen based platforms in local hospital renal department and compare the results with commercial pathology results [8-10].

References:

(1)  X Zhang, B Yao, Q Hu, Y Hong, A Wallace, K Reynolds, C Ramsey, A Maeder, R Reed, Y Tang. Detection of biomarkers in body fluids using bioprobes based on aggregation-induced emission fluorogens. Materials Chemistry Frontiers, 2020, 4 (9), 2548-2570

(2)  Q Hu, D Ding, Y Tang. Inorganic-organic hybrid materials to detect urinary biomarkers: Recent progress and future prospective. Materials Chemistry Frontiers, 2022, 6, 2011-2033

(3)  T Chen, N Xie, L Viglianti, Y Zhou, H Tan, BZ Tang, Y Tang. Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease. Faraday discussions, 2017, 196, 351-362

(4)  ATT Pham, A Wallace, X Zhang, D Tohl, H Fu, C Chuah, KJ Reynolds, C Ramsey, Y Tang. Optical-based biosensors and their portable healthcare devices for detecting and monitoring biomarkers in body fluids. Diagnostics, 2021, 11 (7), 1285.

(5)  ATT Pham, Y Tang. Point-of-care in vitro diagnostics devices based on aggregation-induced emission biosensors: current situation and future prospective. In Volume 1 Aggregation-Induced Emission, 2022, pp. 83-110

(6)  Q Hu, B Yao, TC Owyong, S Prashanth, C Wang, X Zhang, WWH Wong, Y Tang, Y Hong. Detection of Urinary Albumin Using a “Turn‐on” Fluorescent Probe with Aggregation‐Induced Emission Characteristics. Chemistry–An Asian Journal, 2021, 16 (10), 1245-1252.

(7)  S Akraa, APT Tam, H Shen, Y Tang, BZ Tang, J Li, S Walker. A smartphone-based point-of-care quantitative urinalysis device for chronic kidney disease patients. Journal of Network and Computer Applications, 2018, 115, 59-69

(8)  ATT Pham, D Tohl, A Wallace, Q Hu, J Li, KJ Reynolds, Y Tang. Developing a fluorescent sensing based portable medical open-platform-a case study for albuminuria measurement in chronic kidney disease screening and monitoring. Sensing and Bio-Sensing Research, 2022, 100504

(9)  ATT Pham, D Tohl, Q Hu, J Li, KJ Reynolds, Y Tang. Portable colorimetric device with commercial microplates for quantitative detection of urine biomarkers: design, development, and clinical evaluation. Biosensors, 2022, 12 (9), 723.

(10)  D Tohl, MN Teferra, A Wallace, ATT Pham, Y Tang. Re-Referencing and Calibration for Robust Ratiometric Light Intensity Measurement. IEEE Transactions on Instrumentation and Measurement, 2022, 71, 1-8.

个人简介：

  Youhong Tang is a Professor of Materials Science and Engineering and was an Australian Research Council-Discovery Early Career Researcher in Flinders University. He was the Deputy Director of International Laboratory for Health Technologies and ACSRF-Joint Research Centre on Personal Health Technologies and is a Research Leader in Institute for NanoScale Science and Technology (ERA rank 5 in Nanotechnology and Materials Engineering) and a Management Committee in Medical Device Research Institute in Flinders University, Australia. He is a Project Management Professional (PMP) of Project Management Institute (PMI), US since 2008 and was elected as a Fellow of Royal Society of Chemistry (FRSC), UK in 2018, a Fellow of Royal Australia Chemical Institute (FRACI), Australia in 2021 and a Certificated Materials Professional (CMatP), Australia in 2021.

Professor Youhong Tang obtained his PhD degree at the Hong Kong University of Science and Technology in Department of Chemical and Biological Engineering in 2007 and moved to Flinders University in 2012 from the University of Sydney. He is a material science and engineering researcher with research interests mainly focused on (1) Structure-processing-property relationship of polymeric (nano) materials and (2) Chemo/ biosensors and their devices with aggregation-induced emission features.